王翔

发布者:董进 发布时间:2018-09-07 浏览次数:13


王翔

理学博士

教授

教育、科研工作经历

199709—200106河北大学生命科学学院微生物专业大学

200109—200606中国科学院生物物理研究所生物物理学博士

200706—201009挪威卑尔根大学生物医学系博士后

201010—201106挪威卑尔根大学生物医学系高级工程师

201107—201808挪威卑尔根大学生物医学系研究员

  

主要研究方向

细胞间相互作用,微流控技术,膜生物学,细胞凋亡

  

主要学术成果

  长期致力于细胞间相互作用和基于微流控的细胞生物学等领域的研究,在对经由细胞膜纳米管细胞间通讯的研究中有多项重大发现。以第一或通讯作者在PNASCell Death Diff. 等权威杂志发表研究论文十余篇,得到国际同行的广泛关注,被Nature The Scientist等杂志多次报导。独立主持多项挪威国家和地区科研基金。两次获得挪威Meltzers Høyskolefond基金会奖励。为Nature CommunicationJournal Cell BiologyOncotarget等期刊审稿人。

  

代表性论文

第一及通讯作者论文

1.Bittins M, Wang X*. TNT-Induced Phagocytosis: Tunneling nanotubes mediate the transfer of pro-phagocytic signals from apoptotic to viable cells. J Cell Physiol. (2017) 232: 2271-2279 (*通讯作者)

2.Wang X*, Gerdes HH. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Diff. 22 (2015) 1181-1191 (*通讯作者)(The Scientist报导http://www.the-scientist.com/?articles.view/articleNo/43835/title/Mitochondria-Exchange/ )

3.Austefjord MW, Gerdes HH, Wang X*. Tunneling nanotubes: Diversity in morphology and structure. Commun Integr Biol. 7 (2014): e27934. (*通讯作者)

4.Andresen V*, Wang X*, Ghimire S, Omsland M, Gjertsen BT, Gerdes HH. Tunneling nanotube (TNT) formation is independent of p53 expression. Cell Death Diff. 20 (2013):1124. (*第一作者)

5.Wang X*, Bukoreshtliev NV, Gerdes HH. Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes. PLoS One. 7 (2012): e47429. (*第一作者)

6.Mandragon I, Wang X*, Gerdes HH*. Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics. Biomicrofluidics. 6 (2012): 24128. (*通讯作者)

7.Wang X*, Gerdes HH. Long-distance electrical coupling via tunneling nanotubes. Biochim Biophys Acta Biomembrane. 1818 (2012): 2082-2086. (*第一作者)

8.Wang X*, Veruki ML, Bukoreshtliev NV, Hartveit E, Gerdes HH. Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels. Proc Natl Acad Sci U S A. 107 (2010):17194-17199. (*第一作者) (Nature报导引用www.nature.com/news/2010/100920/full/news.2010.482.html

www.nature.com/news/cell-biology-the-new-cell-anatomy-1.9476

www.nature.com/news/how-the-internet-of-cells-has-biologists-buzzing-1.22645)

9.Bukoreshtliev NV*, Wang X*, Hodneland E*, Gurke S, Barroso JF, Gerdes HH. Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Lett. 583 (2009):1481-1488. (*第一作者)

10.Wang X*, Zhao HF, Zhang GJ. Mechanism of cytosol phospholipase C and sphingomyelinase induced lysosome destabilization. Biochimie. 88 (2006): 913-922.(*第一作者)

11.Wang X*, Wang LL*, Zhang GJ. Guanosine 5’-[γ-thio]triphosphate-mediated activation of cytosol phospholipase C caused lysosomal destabilization. J. Membr. Biol. 211 (2006): 55-63. (*第一作者)

  

合作发表论文

1.Gerdes HH, Rustom A, Wang X. Tunneling nanotubes, an emerging intercellular communication route in development. Mechanisms of Development. 130 (2013): 381-387.

2.Wittig D, Wang X, Walter C, Gerdes HH, Funk R, Roehlecke C. Multi-level communication of human retinal pigment epithelial cells via tunneling nanotubes. PLoS One. 7 (2012): e33195.

3.Yi YP, Wang X, Zhang G, Fu TS, Zhang GJ. Phosphatidic acid osmotically destabilizes lysosomes through increased permeability to K+ and H+. Gen. Physiol. Biophys. 25 (2006): 149-160.

4.Zhao HF, Wang X, Zhang GJ. Lysosome destabilization by cytosolic extracts, putative involvement of Ca2+/phospholipase C. FEBS Lett. 579 (2005): 1551-1556.

  

主持项目

  • 项目负责人, Microfluidic device for rapid collection and phenotyping of circulating tumor cells (2016–2018),挪威癌症学会.

  • 博士后项目负责人, Cell-cell interactions during apoptosis of cancer cells (2013–2015),挪威癌症学会.

  • 实验项目负责人, Cell-cell interactions during apoptosis of cancer cells (2013–2016)西挪威卫生局.

  • 项目负责人, Cell-cell interactions during apoptosis of cancer cells (2012–2015),挪威卑尔根研究基金会

      

奖励

  • Meltzers Grant. L. Meltzers Høyskolefond基金会, 挪威, 2017.

  • Career Development Research Fellowship. 挪威癌症学会,2016.

  • Meltzers Grant. L. Meltzers Høyskolefond基金会, 挪威, 2013.

  • Young Researcher Fellowship in Translational Medicine. 挪威卑尔根研究基金会, 2012.