郭 佳

发布者:董进 发布时间:2017-09-11 浏览次数:703


郭佳 博士
E-mail:guojia@cczu.edu.cn

Office:18262255793


郭佳,女,博士,讲师,现年34岁。2011年12月毕业于中国农业大学生物学院微生物与免疫学系(直博),获理学博士学位,师从李季伦院士和文莹教授。2012年2月进入江南大学生物工程学院从事博士后工作,并于2015年1月出站留校任教,2017年7月进入常州大学生物医学工程与健康科学研究院开展研究工作。主要从事细胞生物学与分子生物学等相关科学领域的研究。主持完成江苏省博士后基金1项,在研江苏省自然科学基金青年项目1项,并作为主要成员参与多项国家自然科学基金项目。

主要研究领域:
细胞生物学
分子生物学

教育、工作经历:
2017.07-至今       讲师       常州大学生物医学工程与健康科学研究院
2015.01-2017.07    讲师        细胞生物学        江南大学
2012.02-2015.01    博士后      细胞生物学        江南大学
2006.09-2011.12    直博        微生物分子生物学  中国农业大学
2002.09-2006.06    本科        微生物分子生物学  中国农业大学

主要科研成果:
1. Jia Guo#, Jinlei Zhao#, Lili Li, Zhi Chen, Ying Wen, Jilun Li. (2010) The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol Genet Genomics 283:123–133.
2. Jia Guo#, Xuan Zhang#, Zhi Chen, Ying Wen, Jilun Li. (2013) A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. PloS One 8(8): e71330.
3. Jia Guo, Xuan Zhang, Zhi Chen, Ying Wen, Jilun Li. (2014) Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. PloS One 9(6): e99224.
4. Jia Guo, Zengqi Tan, Wei Lu, Ganglong Yang, Feng Guan. (2014) Alteration of N-glycans and expression of its related glycogenes in epithelial-mesenchymal transition of HCV29 bladder epithelial cells. Molecules 19(12), 20073-20090.
5. Jia Guo, Bo Song, Xiang Li, Chenhui He, Ganglong Yang, Feng Guan. (2015) Down-regulation of gangliotetraosylceramide (Gg4) and β3GalT4 gene expression by Smads during TGF-β-induced epithelial-mesenchymal transition. Mol Med Rep 11(3): 2241-2247.
6. Jia Guo#, Yicheng Wang#, Bo Song, Xin Wang, Ganglong Yang, Feng Guan. (2015) Identification and functional characterization of intracellular sialidase NeuA3 from Streptomyces avermitilis. Process Biochem 50(5): 752-758.
7. Jia Guo#, Changmei Liu#, Xiaoman Zhou, Xiaoqiang Xu, Linhong Deng, Xiang Li, Feng Guan. (2017) Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells. Int J Mol Sci 18, 1528; doi:10.3390/ijms18081528.
8. Zengqi Tan, Wei Lu, Xiang Li, Ganglong Yang, Jia Guo, Hanjie Yu, Zheng Li, Feng Guan. (2014) Altered N-glycan expression profile in epithelial-to-mesenchymal transition of NMuMG cells revealed by an integrated strategy using mass spectrometry and glycogene and lectin microarray analysis. J Proteome Res 13 (6): 2783-2795.
9. Feng Guan, Xiang Li, Jia Guo, Ganglong Yang, Xiang Li. (2015) Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cellsInternational. Int J Nanomed 10: 1-12.
10. Ganglong Yang, Zengqi Tan, Wei Lu, Jia Guo, Hanjie Yu, Jingmin Yu, Chengwen Sun, Xiaowei Qi, Zheng Li, Feng Guan. (2015) Quantitative glycome analysis of N-glycan patterns in bladder cancer vs. normal bladder cells using an integrated strategy. J Proteome Res 14,639-653.
11. 授权专利:关锋、李想、杨刚龙、郭佳、刘昌梅,一种细菌纳米磁小体–凝集素复合物及其制备方法与应用,专利号:ZL201510075253.X