邓林红

发布者:董进 发布时间:2014-09-29 浏览次数:13586


邓林红,男,1960年7月生,汉族,四川夹江人,当前国际生物力学界最为活跃的青年科学家之一。近年来的研究主要针对哮喘病等呼吸道疾病的生理病理机制,在微纳米尺度下研究细胞的动力学行为规律,特别是细胞对应力-应变等物理因素刺激的响应及其引发的结构与功能变化在哮喘病生理病理过程中的作用。在细胞骨架动力学,细胞对机械刺激的响应等方面取得了一系列重要的成果,在《Nature》、《Nature Materials》等国际一流学术杂志上发表了一系列高水平的研究论文,其中《Nature Materials》论文当选美国《Science Watch》2008年材料科学领域“快速突破论文”。 2007年作为高水平引进人才回国工作后,已主持承担和完成了多项国家和省部级科研项目,发表研究论文60余篇,其中SCI收录40余篇,申报专利1项,获得“全国侨界创新贡献奖”,重庆市“科技领军人才奖”,“全国优秀教学论文一等奖”等奖项。2008年当选教育部“长江学者奖励计划”特聘教授。


Email:dlh@cczu.edu.cn


现任职务:
    常州大学生物医学工程与健康科学研究院院长
    常州大学护理学院副院长(兼)
    美国哈佛大学公共卫生学院客座科学家
    美国医学与生物工程院会士
    中国生物物理学会理事
    中国生物医学工程学会高级会员
    中国光学会生物医学光子学专业委员会常务委员
    中国生物材料学会会员
    江苏省力学学会生物力学专业委员会主任委员
    美国纽约科学院会员
    美国电子电器工程师学会会员
    Journal of Biomechanics(生物力学杂志)、Journal of Biochimica et Biophysica Acta(生物化学与生物物理文摘杂志)、AJP Cell(美国生理学杂志细胞生理学)、AJP Heart(心脏与循环生理学)等国际一流杂志审稿人等。


教育、工作经历:
        1982年7月以优异成绩毕业于重庆大学机械工程二系。1986年7月获得重庆大学生物力学与生物流变学硕士学位并留校从事生物力学科研与教学工作。1988年9月–1990年9月,任重庆大学生物工程中心讲师,并担任重庆维多生物工程技开发公司总经理。1990年9月–1992年9月,获中英友好奖学金资助赴英国斯查克莱德大学生物工程专业访学,1992年9月–1998年7月,在英国斯查克莱德大学生物工程系攻读并获博士学位,1998年7月-2000年8月,担任英国斯查克莱德大学生物工程系助理研究员。2000年9月-2004年2月,赴加拿大达豪斯大学(Dalhousie University) 生物医学工程学院从事博士后研究,并担任细胞力学实验室主任。2004年2月-2007年3月,担任美国哈佛大学公共卫生学院研究员。
       2007年-2012年间,受聘教育部“长江学者奖励计划”特聘教授;担任重庆大学生物工程学院教授、博士导师;重庆大学“国家985工程”科技创新平台-生物流变学与基因调控新技术研究院院长;生物流变科学与技术教育部重点实验室主任;重庆大学生物医学工程国家一级重点学科带头人;重庆市生物医学工程学科学术带头人;重庆市首批高校创新团队负责人;加拿大哈利法克斯生物医学有限公司科学顾问、名誉董事等职务。
    此外,还担任众多国际重要学术会议主要职务。2001年10月,担任第4届中国科学青年科学家大会主席团成员、学术委员会成员、生物技术专题分会主席;2005年5月,担任第12届国际生物流变学大会平滑肌分会主席;2007年11月,担任第6届平滑肌与炎症青年科学家国际会议平滑肌应力应变分会场主席;2008年6月,担任第2届国际非均质材料力学会议生物启发材料力学分会场主席;2009年10月,担任中-德先进生物材料与纳米器件国际会议中方主席;2009年10月 ,担任中-加气道平滑肌与哮喘病双边高层国际会议中方主席。


主要研究领域:
细胞生物微流变学,细胞纳米显微成像,多维显微成像术,纳米生物光子学,分子力学与成像术,生物流变学与芯片实验室技术, 磁微粒在生物医学工程中的应用,干细胞分化的物理调控与组织修复,纳米材料表征与细胞生物学行为的调控机制,细胞流变行为在哮喘等疾病的病理生物学中的作用等。


曾获奖项与荣誉:
   中英友好奖学金(1990-1991)
   国际生物流变学会旅行奖(1992)
   英国ORS 奖学金和英国斯查克莱德大学利文斯通奖学金(1991-1995)
   美国实验生物学联合会(FASEB)平滑肌研究青年科学家奖(2003)
   汤姆森科技Science Watch评选的世界材料科学领域 Fast Breaking Paper (2008)
   Marquis美国名人录(2009)
   Marquis世界名人录(2010)
   中国政府特殊津贴人才(2010)
   中国侨界贡献(创新人才)奖(2010)
   重庆市百名科技领军人物正式人选(2010)
   “江苏省高层次创新创业人才引进计划”重点学科引进人才(2012)
先后被接受为美国纽约科学院会员、美国IEEE学会会员,多次应邀作为国际专家组成员为美国应用生理学杂志、欧洲呼吸杂志撰写关于气道平滑肌应力应变关系和气道平滑肌动力学与气道阻塞的特邀报告。


主要论文:

  1. Chen J, Jiang X, Duan Y, Long J, Bartsch JW, Deng L*. ADAM8 in Asthma: Friend or Foe to Airway Inflammation? AJRCMB, 2013 (In press).

  2. Liu YH, Chen YB, Jiang CM, Li BK, Tang YL, Hu L, Deng L*. Depletion Effect and Biomembrane Budding. J of Biological Physics, 2013 (In press).

  3. Lin F, Song A, WU J, Jiang X, Long J, Chen J, Duan Y, Shi Y, Deng L*. ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats. Molecular Medicine Reports, DOI: 10.3892/mmr.2013.1621, (In press), 2013.

  4. Chen L, Ge Q, Black JL, Deng L. Burgess JK, Oliver BGG. Differential regulation of extracellular matrix and soluble fibulin-1 levels by TGF-1 in airway smooth muscle cells. PlosOne, 8(6): e65544. doi:10.1371/journal.pone.0065544, 2013.

  5. Deng L. Image-based in vivo quantitative assessment of human airway opening and contractility by fiber optical nasopharyngoscopy in healthy and asthmatic subjects. Journal of Innovative Optical Health Sciences, 6(2):1350013(12 pages), 2013.

  6. Shi YL, Dong YH, Duan YY, Jiang XM, Chen C, Deng L. Substrate stiffness influences TGF-b1-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodelling. Molecular Medicine Reports, 7:49-424, 2013.

  7. Zhao HB, Wang YS, Jiang XM, et al. In vitro assay of cytoskeleton nanomechanics as a tool for screening potential anticancer effects of natural plant extract, tubeimoside I on human hepatoma (HepG2) cells. Chin Sci Bull, 58: 58:2572–2579, 2013.

  8. West AR, Syyong HT, Siddiqui S, Pascoe CD, Murphy TM, Maarsingh H, Deng L, Maksym GN, Bossé Y. Airway contractility and remodeling: Links to asthma symptoms. Pulm Pharmacol Ther. 26:3-12,2013.

  9. Chen Y., Maksym G.N., Brown T., L.Deng. Determination of glottic opening fluctuation by a new method based on nasopharyngoscopy. Chinese Journal of Physiology, 56(1):52-57, 2013.

  10. Long, J. Li, M., Ren, Q., Zhang, C., Fan, J., Duan, Y., Chen, J., Li, B., Deng, L. Phylogenetic and molecular evolution of the ADAM (A Disintegrin And Metalloprotease) gene family from Xenopus tropicalis, to Mus musculus, Rattus norvegicus, and Homo sapiens. Gene. 507:36-43, 2012.

  11. Yan, H., Jiang, W., Zhang, Y., Liu, Y., Wang, B., Yang, L., Deng, L., Singh, G. K., Pan, J., Novel multi-biotin grafted poly(lactic acid) and its self-assembling nanoparticles capable of binding to streptavidin. International journal of nanomedicine. 7:457-465, 2012.

  12. Chen, L., Sun, C., Deng, L. [The study of beta2-adrenergic receptor gene polymorphism in Sanda athletes]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (Journal of biomedical engineering, a Chinese Language journal). 29:129-133, 2012.

  13. Wang Guixue, Wei Dangheng; Tang Chaojun; Qiu Juhui; Zhao Jingbo; Gregersen Hans; Deng, L. Upregulation of SDF-1 is associated with atherosclerosis lesions induced by LDL concentration polarization, Annals of Biomedical Engineering, 40 (5):1018-27, 2012.

  14. Xu J, Chen C, Jiang X, Xu R, Tambe D, Zhang X, Liu L, Lan B, Cai K, Deng L. Effects of micropatterned curvature on the motility and mechanical properties of airway smooth muscle cells. Biochem Biophys Res Commun, 415:591-6, 2011.

  15. Deng L, Jiang X, Chen C, Song A, Lin F. Optically tracking the motion of microbeads to study physical behaviors of the living cell in response to transient stretch or compression. Journal of Innovative Optical Health Sciences. 4 (2):143-50, 2011.

  16. Wang YS, Deng LH, Zhong HZ, Wang YJ, Jiang XM, Chen J. Natural Plant Extract Tubeimoside I Promotes Apoptosis-Mediated Cell Death in Cultured Human Hepatoma (HepG2) Cells. Biological & Pharmaceutical Bulletin, 34 (6):831-8, 2011.

  17. Wang Y, Deng L, Wang Y, Zhong H, Jiang X, Chen J. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells. Molecular Medicine Reports. 4:713-718, 2011.

  18. Wang YQ, Tang ZY, Xue RY, Singh GK, Lv YG, Shi KN, Cai KY, Deng LH, Yang L. TGF-beta 1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-kappa B. Connective Tissue Research, 52 (3):218-25, 2011.

  19. Lv Z, Wang J, Chen G, Deng L. Imaging and determining friction forces of specific interactions between human IgG and rat anti-human IgG. Journal of Biological Physics, 37(4):417-427, 2011.

  20. Deng L, Jiang X, Chen C, Xu J, Shi Y, Zhao Y. Multiscale biomechanical behaviors of heterogeneous airway smooth muscle cells. In: Fan J, Zhang J, CHen H, Jin Z, editors. Proceedings of The Third International Conference on Heterogeneous Material Mechanics. Shanghai, China: Advances in Heterogeneous Material Mechanics. DEStech Publications, Inc., pp. 1136-41, 2011.

  21. Wang, B., Jiang, W., Yan, H., Zhang, X., Yang, L., Deng, L., Singh, G. K., Pan, J. Novel PEG-graft-PLA nanoparticles with the potential for encapsulation and controlled release of hydrophobic and hydrophilic medications in aqueous medium. International Journal of Nanomedicine, 6:1443-1451, 2011.

  22. Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L*, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One, 5 (8):e12035, 2010.

  23. Pan J, Zhang TX, Mi L, Zhang BB, Wang B, Yang L, Deng LH, Wang LY. Stepwise Increasing and Decreasing Fluid Shear Stresses Differentially Regulate the Functions of Osteoblasts. Cellular and Molecular Bioengineering, 3 (4):376-86, 2010.

  24. Lv ZJ, Wang JH, Chen GP, Deng LH. Probing Specific Interaction Forces Between Human IgG and Rat Anti-Human IgG by Self-Assembled Monolayer and Atomic Force Microscopy. Nanoscale Research Letters, 5 (6):1032-8, 2010.

  25. Lv ZJ, Wang JH, Chen GP, Deng LH. Imaging recognition events between human IgG and rat anti-human IgG by atomic force microscopy. International Journal of Biological Macromolecules, 47 (5):661-7, 2010.

  26. Lv ZJ, Wang JH, Deng LH, Chen GP. Preparation and Characterization of Covalently Binding of Rat Anti-human IgG Monolayer on Thiol-Modified Gold Surface. Nanoscale Research Letters. 4 (12):1403-8, 2009.

  27. Deng L, Bosse Y, Brown N, Chin LYM, Connolly, SC, Fairbank NJ, King GG, Maksym GN, Pare, PD, Seow CY, Stephen NL. Stress and strain in the contractile and cytoskeletal filaments of airway smooth muscle. Pulmonary Pharmacology & Therapeutics, 22:407-416, 2009.

  28. Hu Y, Cai K, Luo Z, Zhang R, Yang L, Deng L, Jandt KD. Surface mediated in situ differentiation of mesenchymal stem cells on gene-functionalized titanium films fabricated by layer-by-layer technique. Biomaterials, 30(21):3626-35, 2009.

  29. Song, Aijing, Liu, Chundong, Wang, Jianhua, Deng, Linhong. Sulfoakyl ether β-cycledextrin derivatives synthesized by a single step method as pharmaceutical biomaterials.  Chinese Science Bulletin, 54(2): 3187-3199, 2009.

  30. Fairbank, Nigel J., Sarah C.Connolly, James D.MacKinnon, Kathrin Wehry, Linhong Deng, Geoffrey N.Maksym. Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain. Am J Physiol Lung Cell Mol Physiol, 295(3): L479-488, 2008.

  31. Kaiyong Cai, Yan Hu, Zhong Luo, Ting Kong, Min Lai, Xiaojing Sui, Yuanliang Wang, Li Yang, Linhong Deng. Cell-Specific Gene Transfection from a Gene-Functionalized Poly(lactic acid) Substrate Fabricated by the Layer-by-Layer Assembly Technique. Angewandte Chemie International Edition 47(39): 7479-7481, 2008.

  32. Deng, Linhong., Dynamics of the cytoskeleton: A portrait of living cells as heterogeneous and nonequilibrial materials, in Advances in Heterogeneous Material Mechanics, DESTECH PUBLICATIONS INC: Lancaster. p. 582-587, 2008.

  33. Xavier Trepat, Linhong Deng, Steve S. An, Daniel Nevajas, Daniel J Tschumperlin, Willliam T. Gerthoffer, James P. Butler, and Jeffrey J. Fredberg. Universal physical responses to stretch in the living cell. Nature 447:592-595, 31 May, 2007.

  34. An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T2, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PSP, Smith PG, Solway J,  Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L.  (Authors are in alphabetic order and members of an ad hoc expert discussion panel on airway smooth muscle structure and function). Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. European Respiratory J 29:834-860, 2007.

  35. Cai, Kaiyong, Zhang,Jun, Deng, Linhong, Li Yang, Yan Hu, Lei Xu. Physical and biological properties of a novel hydrogel composite based on oxidized alginate, gelatin and tricalcium phosphate for bone tissue engineering. Advanced Engineering Materials. Vol. 9:1082-1088, 2007.

  36. Deng, Linhong, Xavier Trepat, James P. Butler, Emil Millet, Kathleen G. Morgan, David A. Weitz and Jeffrey J. Fredberg. Fast and slow dynamics of the cytoskeleton. Nature Materials 5:636-640, 2006.

  37. Deng, L, NJ Fairbank, DJ Cole, JJ Fredberg and GN Maksym.  Airway smooth muscle tone modulates mechanically induced cytoskeletal stiffening and remodeling.  J Appl Physiol 99: 634-641, 2005.

  38. Maksym, GN, Deng, L, Fairbank, NJ, Lall, CA, and SC Connoly: Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle. Canadian Journal of physiology and Pharmacology 83:913-922, 2005.

  39. Bai TR, Bates JH, Brusasco V, Camoretti-Mercado B, Chitano P, Deng LH, Dowell M, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Hai CM, Halayko AJ, Hirst SJ, James AL, Janssen LJ, Jones KA, King GG, Lakser OJ, Lambert RK, Lauzon AM, Lutchen KR, Maksym GN, Meiss RA, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Schellenberg RR, Seow CY, Sieck GC, Smith PG, Smolensky AV, Solway J, Stephens NL, Stewart AG, Tang DD, Wang L.  On the terminology for describing the length-force relationship and its changes in airway smooth muscle (An invited editorial). J Appl Physiol. 97(6):2029-34, 2004.

  40. Deng, L, NJ Fairbank, B Fabry, PG Smith, GN Maksym.  Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells.  Am J Physiol: Cell Physiol.  287: C440-448, 2004.

  41. Smith, P.G., Deng, L., Fredberg, J.J. and G.N. Maksym: Mechanical Strain Increases Cell Stiffness Through Cytoskeletal Filament Reorganization. American Journal of Physiology: Lung Cellular and Molecular Physiology 285(2):L456-63, 2003.

  42. Deng, L.H., J.C.Barbenel and Lowe, G.D.O: Influence of hematocrit on the erythrocyte aggregation kinetics for suspension of red blood cells in autologous plasma, Biorheology, 31:193-205, 1994.

  43. Deng, L.H., Y.P.Wu, G.R.Wang, R.F.Yang and Lee J.S.: The Fahraeus effect in sheet flows with a gap thickness of 4 to 36 m. Trans. ASME J. of Biomechanical Engineering, 111:32-36, 1989.